GABRB2

Across TCGA patient cohorts, GABRB2 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GABRB2-associated genes across cancer lineages are Annexin-1, C-Raf, and TAZ. Each is linked with GABRB2 in more than 2 cancer types. Because this analysis shows association rather than direction, both GABRB2-to-partner and partner-to-GABRB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by GABRB2-low versus GABRB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GABRB2→partner) and Y-score (partner→GABRB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.497	+2.807	<.001	<.001	3	3
UCEC	C-Raf →	+0.100	+1.321	.010	.027	3	3
SKCM	TAZ →	+0.122	+1.427	.015	.026	3	2
UCEC	JNK2 →	+0.155	+1.584	.004	<.001	3	2
UCEC	MEK1 →	+0.373	+2.169	<.001	<.001	3	2
UCEC	PDCD4 →	-0.440	-1.633	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Annexin-1 by GABRB2 expression — UCEC

Explore this box plot interactively →