GABRB2

Across TCGA cell cohorts, GABRB2 mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GABRB2-associated genes across cancer lineages are DUXA, CST11, and RGR. Each is linked with GABRB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GABRB2-to-partner and partner-to-GABRB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DUXA grouped by GABRB2-low versus GABRB2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GABRB2→partner) and Y-score (partner→GABRB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DUXA →	+0.033	+3.043	<.001	.006	3	2
LUNG_NSCLC_LUAD	CST11 →	+0.074	+3.472	<.001	.004	3	1
LUNG_NSCLC_LUAD	RGR →	+0.010	+3.803	.004	<.001	3	1
LUNG_NSCLC_LUAD	KLF18 →	+0.025	+2.882	<.001	.009	3	1
LUNG_NSCLC_LUAD	POU1F1 →	+0.038	+3.273	<.001	.003	3	1
LUNG_NSCLC_LUAD	PAX7 →	+0.610	+2.882	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

DUXA by GABRB2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →