Across TCGA patient cohorts, GABRA5 mutation is significantly associated with the RNA expression of many other genes, with 4,110 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GABRA5-associated genes across cancer lineages are EFCAB11, PSMB6, and KIF2C. Each is linked with GABRA5 in more than 3 cancer types. Because this analysis shows association rather than direction, both GABRA5-to-partner and partner-to-GABRA5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GABRA5→partner) and Y-score (partner→GABRA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	EFCAB11 →	+0.268	+3.047	.007	<.001	3	4
UCEC	PSMB6 →	+0.384	+1.840	<.001	<.001	3	4
UCEC	KIF2C →	+0.485	+1.458	.009	.001	3	4
LUAD	EIF5A →	+0.418	+2.438	.003	.001	3	4
UCEC	TIMM22 →	+0.410	+2.098	<.001	<.001	3	4
LUAD	FAM136A →	+0.330	+3.345	.007	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,110 associations by consensus.

Exploration

GABRA5 survival (RNA) · tumor vs normal (RNA) · all GABRA5 data types