Across TCGA patient cohorts, GABRA5 mutation is significantly associated with the total protein of many other genes, with 68 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GABRA5-associated genes across cancer lineages are mTOR_pS2448, PAI-1, and E-Cadherin. Each is linked with GABRA5 in more than 3 cancer types. Because this analysis shows association rather than direction, both GABRA5-to-partner and partner-to-GABRA5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GABRA5→partner) and Y-score (partner→GABRA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	mTOR_pS2448 →	-0.214	-2.431	.007	.019	3	4
COAD	PAI-1 →	+0.552	+3.017	.010	.017	3	4
COAD	E-Cadherin →	-0.470	-2.321	.040	.032	3	4
UCEC	FoxM1 →	+0.166	+1.530	.033	.004	3	4
COAD	G6PD →	+0.148	+2.338	.030	.017	3	3
COAD	MIG-6 →	+0.075	+1.966	.037	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

Exploration

GABRA5 survival (RNA) · tumor vs normal (RNA) · all GABRA5 data types