Across TCGA cell cohorts, GABRA5 mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. LUNG_NSCLC_LUSC shows the largest number of these associations.

The most reproducible GABRA5-associated genes across cancer lineages are TPD52L3, CST9L, and RLN3. Each is linked with GABRA5 in more than 1 cancer types. Because this analysis shows association rather than direction, both GABRA5-to-partner and partner-to-GABRA5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GABRA5→partner) and Y-score (partner→GABRA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TPD52L3 →	+0.048	+3.684	<.001	.006	3	2
SOFT_TISSUE	CST9L →	+0.028	+5.369	<.001	.004	3	1
SOFT_TISSUE	RLN3 →	+0.059	+5.369	<.001	.004	3	1
URINARY_TRACT	SLC22A12 →	+0.006	+5.087	<.001	.004	3	1
LUNG_NSCLC_LUSC	GJA8 →	+0.060	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	DEFA6 →	+1.943	+4.643	.002	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Exploration

GABRA5 survival (RNA) · tumor vs normal (RNA) · all GABRA5 data types