GABRA2

Across TCGA cell cohorts, GABRA2 mutation is significantly associated with the RNA expression of many other genes, with 175 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GABRA2-associated genes across cancer lineages are BEST3, MYOCD, and CALHM4. Each is linked with GABRA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GABRA2-to-partner and partner-to-GABRA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BEST3 grouped by GABRA2-low versus GABRA2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GABRA2→partner) and Y-score (partner→GABRA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	BEST3 →	+0.541	+3.389	<.001	.007	3	1
SKIN	MYOCD →	+0.910	+3.629	<.001	.003	3	1
SKIN	CALHM4 →	+0.054	+3.076	<.001	.002	3	1
SKIN	FNDC1 →	+0.568	+3.064	.002	.009	3	1
SKIN	LIPF →	+0.032	+2.560	.001	.008	3	1
SKIN	MRLN →	+0.064	+2.556	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 175 associations by consensus.

BEST3 by GABRA2 expression — SKIN

Explore this box plot interactively →