GABPB1

Across TCGA patient cohorts, GABPB1 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GABPB1-associated genes across cancer lineages are Notch1, EGFR_pY1068, and eIF4E. Each is linked with GABPB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GABPB1-to-partner and partner-to-GABPB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by GABPB1-low versus GABPB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GABPB1→partner) and Y-score (partner→GABPB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.238	+3.920	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.329	-3.392	<.001	<.001	3	1
UCEC	eIF4E →	+0.214	+2.247	.005	.001	3	1
UCEC	eIF4G →	+0.351	+3.584	.002	.002	3	1
UCEC	A-Raf_pS299 →	-0.141	-3.000	.001	<.001	3	1
UCEC	ERK2 →	+0.197	+1.847	.005	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

Notch1 by GABPB1 expression — UCEC

Explore this box plot interactively →