GABPA

Across TCGA pan-cancer cohorts, GABPA mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GABPA data layer compared with 23 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher GABPA mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated GABPA expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

UCEC, PDAC, and LUAD are the cancer types where GABPA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	III,IV	0.238	1.000	.003	36	view →
PDAC	DFS	Tertile	All	0.941	0.629	<.001	33	view →
LUAD	DFS	Tertile	All	0.780	0.466	.003	19	view →
COAD	DFS	Quartile	II,III,IV	0.898	1.000	.042	6	view →
LSCC	OS	Tertile	All	0.959	0.727	.007	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

GABPA–UCEC (DFS)

Open the UCEC breakdown →