GABPA

Across TCGA patient cohorts, GABPA mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GABPA-associated genes across cancer lineages are ATM, p27, and Caspase-8. Each is linked with GABPA in more than 3 cancer types. Because this analysis shows association rather than direction, both GABPA-to-partner and partner-to-GABPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by GABPA-low versus GABPA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GABPA→partner) and Y-score (partner→GABPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.491	-2.446	.005	.018	3	4
UCEC	p27 →	+0.204	+2.700	.017	.006	3	2
UCEC	Caspase-8 →	-0.255	-2.673	.009	.005	3	2
UCEC	14-3-3_beta →	-0.092	-3.295	.019	.009	3	1
UCEC	EGFR_pY1068 →	-0.199	-1.584	.043	.036	3	1
UCEC	eIF4E →	+0.182	+2.000	.027	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

ATM by GABPA expression — UCEC

Explore this box plot interactively →