GABPA

Across TCGA cell cohorts, GABPA mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GABPA-associated genes across cancer lineages are CLDN17, IQCF3, and KRTAP19-3. Each is linked with GABPA in more than 1 cancer types. Because this analysis shows association rather than direction, both GABPA-to-partner and partner-to-GABPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLDN17 grouped by GABPA-low versus GABPA-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GABPA→partner) and Y-score (partner→GABPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CLDN17 →	+0.018	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	IQCF3 →	+0.049	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	KRTAP19-3 →	+0.132	+5.228	<.001	.005	3	1
LARGE_INTESTINE	SLC39A14 →	+1.094	+3.067	<.001	.009	3	1
LARGE_INTESTINE	ACOT12 →	+0.033	+2.672	<.001	.004	3	1
LARGE_INTESTINE	LY6G6F →	+0.112	+2.560	.003	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

CLDN17 by GABPA expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →