GABBR2

Across TCGA patient cohorts, GABBR2 mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GABBR2-associated genes across cancer lineages are MYH11, GAPDH, and Cyclin-B1. Each is linked with GABBR2 in more than 4 cancer types. Because this analysis shows association rather than direction, both GABBR2-to-partner and partner-to-GABBR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYH11 grouped by GABBR2-low versus GABBR2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GABBR2→partner) and Y-score (partner→GABBR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MYH11 →	-1.181	-3.160	.011	.019	3	4
COAD	GAPDH →	+0.516	+1.593	.009	.043	2	5
UCEC	Cyclin-B1 →	+0.519	+1.777	.003	.002	3	3
UCEC	4E-BP1_pT37_T46 →	-0.305	-1.289	.010	.023	3	3
COAD	Mre11 →	+0.092	+2.334	.048	.018	3	3
LUSC	Beclin →	+0.293	+3.000	<.001	.035	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

MYH11 by GABBR2 expression — LUSC

Explore this box plot interactively →