GABBR2

Across TCGA cell cohorts, GABBR2 mutation is significantly associated with the RNA expression of many other genes, with 329 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GABBR2-associated genes across cancer lineages are RWDD3, HHLA1, and SGCZ. Each is linked with GABBR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GABBR2-to-partner and partner-to-GABBR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RWDD3 grouped by GABBR2-low versus GABBR2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GABBR2→partner) and Y-score (partner→GABBR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RWDD3 →	+0.365	+3.169	.008	.009	3	2
BLOOD_Leukemia	HHLA1 →	+0.004	+3.381	.004	.002	3	1
BLOOD_Leukemia	SGCZ →	+0.464	+3.675	.001	.003	3	1
SKIN	GALNT8 →	+0.444	+3.584	<.001	.004	3	1
SKIN	DPEP3 →	+0.871	+2.817	.004	.007	3	1
SKIN	DTHD1 →	+0.034	+3.648	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 329 associations by consensus.

RWDD3 by GABBR2 expression — LARGE_INTESTINE

Explore this box plot interactively →