GABARAP

Across TCGA pan-cancer cohorts, GABARAP mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated GABARAP data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher GABARAP mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated GABARAP expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

GBM, CCRCC, and LSCC are the cancer types where GABARAP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Median	All	0.642	0.772	.006	13	view →
CCRCC	DFS	Median	All	1.000	0.907	.022	9	view →
LSCC	OS	Quartile	All	1.000	0.788	.005	5	view →
LUAD	DFS	Median	II,III,IV	0.651	0.360	.037	5	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

GABARAP–GBM (DFS)

Open the GBM breakdown →