GABARAP

Across TCGA pan-cancer cohorts, GABARAP mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of GABARAP’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where GABARAP mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types GABARAP is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

LUAD, COAD, and PDAC are the cancer types where GABARAP tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GABARAP mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	+0.687	<.001	9	view →
COAD	All	III,IV	+0.213	<.001	8	view →
PDAC	Male	III,IV	−0.997	.001	6	view →
LSCC	All	All	+0.163	<.001	5	view →
CCRCC	All	II,III,IV	+0.217	.010	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

GABARAP–LUAD

Open the LUAD breakdown →