Across TCGA patient cohorts, GAB4 mutation is significantly associated with the RNA expression of many other genes, with 2,746 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GAB4-associated genes across cancer lineages are GIT1, MVK, and AUP1. Each is linked with GAB4 in more than 3 cancer types. Because this analysis shows association rather than direction, both GAB4-to-partner and partner-to-GAB4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAB4→partner) and Y-score (partner→GAB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GIT1 →	+0.384	+3.721	.002	<.001	3	3
LUAD	MVK →	+0.454	+2.526	<.001	.001	3	3
SKCM	AUP1 →	+0.319	+3.561	.003	.002	3	3
SKCM	ITGB1BP1 →	+0.570	+2.446	<.001	.001	3	3
UCEC	ZWINT →	+0.621	+3.988	.003	<.001	3	3
SKCM	TUBG1 →	+0.463	+3.208	.002	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,746 associations by consensus.

Exploration

GAB4 survival (RNA) · tumor vs normal (RNA) · all GAB4 data types