Across TCGA patient cohorts, GAB4 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GAB4-associated genes across cancer lineages are 4E-BP1, Cyclin-B1, and FoxM1. Each is linked with GAB4 in more than 3 cancer types. Because this analysis shows association rather than direction, both GAB4-to-partner and partner-to-GAB4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAB4→partner) and Y-score (partner→GAB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	4E-BP1 →	+0.440	+3.584	.001	.002	3	4
LUAD	Cyclin-B1 →	+0.780	+3.321	<.001	.009	3	4
LUAD	FoxM1 →	+0.403	+2.334	<.001	.018	3	2
LUAD	TFRC →	+0.687	+3.000	.004	.034	3	2
LUAD	XRCC1 →	+0.134	+2.195	.047	.033	3	2
LUSC	P-Cadherin →	+0.199	+3.169	.044	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

Exploration

GAB4 survival (RNA) · tumor vs normal (RNA) · all GAB4 data types