Across TCGA cell cohorts, GAB4 RNA expression is significantly associated with the mutation status of many other genes, with 65 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible GAB4-associated genes across cancer lineages are FLOT2, LRRK1, and MKI67. Each is linked with GAB4 in more than 1 cancer types. Because this analysis shows association rather than direction, both GAB4-to-partner and partner-to-GAB4 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAB4→partner) and Y-score (partner→GAB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	FLOT2 →	+3.716	+0.097	.003	.001	3	2
LUNG_SCLC	LRRK1 →	+2.807	+0.195	.001	<.001	3	2
BLOOD_Leukemia	MKI67 →	+2.121	+0.021	.007	.006	3	2
BONE	C7 →	+4.000	+0.295	.008	.008	3	1
LUNG_NSCLC_LUSC	RHOT1 →	+4.643	+0.073	.008	<.001	3	1
LUNG_NSCLC_LUSC	TEX2 →	+4.643	+0.073	.008	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

Exploration

GAB4 survival (RNA) · tumor vs normal (RNA) · all GAB4 data types