Across TCGA cell cohorts, GAB4 mutation is significantly associated with the RNA expression of many other genes, with 109 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GAB4-associated genes across cancer lineages are OR1K1, C10orf120, and FAM25G. Each is linked with GAB4 in more than 1 cancer types. Because this analysis shows association rather than direction, both GAB4-to-partner and partner-to-GAB4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAB4→partner) and Y-score (partner→GAB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR1K1 →	+0.014	+4.369	<.001	.008	3	1
SOFT_TISSUE	C10orf120 →	+0.022	+4.977	<.001	.002	3	1
SOFT_TISSUE	FAM25G →	+1.376	+4.635	<.001	.003	3	1
SOFT_TISSUE	LYZL6 →	+0.014	+4.369	<.001	.008	3	1
LUNG_SCLC	OR4D6 →	+0.017	+4.643	<.001	.004	3	1
LUNG_SCLC	GKN1 →	+0.310	+4.044	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 109 associations by consensus.

Exploration

GAB4 survival (RNA) · tumor vs normal (RNA) · all GAB4 data types