GAB3

Across TCGA pan-cancer cohorts, GAB3 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated GAB3 data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher GAB3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated GAB3 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

LUAD and PDAC are the cancer types where GAB3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	II,III,IV	0.836	0.286	.004	15	view →
PDAC	DFS	Tertile	All	0.841	0.340	.024	9	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

GAB3–LUAD (DFS)

Open the LUAD breakdown →