GAB3

Across TCGA patient cohorts, GAB3 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GAB3-associated genes across cancer lineages are NF-kB-p65_pS536, PCNA, and c-Met_pY1235. Each is linked with GAB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GAB3-to-partner and partner-to-GAB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NF-kB-p65_pS536 grouped by GAB3-low versus GAB3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAB3→partner) and Y-score (partner→GAB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NF-kB-p65_pS536 →	-0.332	-2.459	.029	.018	3	2
UCEC	PCNA →	+0.226	+3.700	.001	.001	3	2
UCEC	c-Met_pY1235 →	+0.064	+2.201	.010	<.001	3	2
UCEC	Cyclin-B1 →	+0.460	+1.584	.014	.009	3	2
UCEC	eIF4E →	+0.183	+1.874	.009	.002	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.377	+1.916	.027	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

NF-kB-p65_pS536 by GAB3 expression — UCEC

Explore this box plot interactively →