GAB3

Across TCGA cell cohorts, GAB3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,306 significant associations in total. BONE shows the largest number of these associations.

The most reproducible GAB3-associated GO terms across cancer lineages are Regulation of cell-substrate junction organization, Positive regulation of supramolecular fiber organization, and Positive regulation of cytoskeleton organization. Each is linked with GAB3 in more than 12 cancer types. Because this analysis shows association rather than direction, both GAB3-to-partner and partner-to-GAB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cell-substrate junction organization grouped by GAB3-low versus GAB3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GAB3→partner) and Y-score (partner→GAB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of cell-substrate junction organization →	+0.143	+0.666	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Positive regulation of supramolecular fiber organization →	+0.111	+0.944	.001	.004	3	11
LUNG_NSCLC_LUSC	Positive regulation of cytoskeleton organization →	+0.099	+1.007	.001	.001	3	10
BONE	Regulation of focal adhesion assembly →	+0.154	+0.665	<.001	<.001	3	10
BONE	Positive regulation of focal adhesion assembly →	+0.210	+0.713	<.001	<.001	3	10
BONE	Regulation of cell-substrate junction assembly →	+0.154	+0.665	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,306 associations by consensus.

Regulation of cell-substrate junction organization by GAB3 expression — BONE

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