GAB2

Across TCGA patient cohorts, GAB2 protein abundance is significantly associated with the RNA expression of many other genes, with 5,657 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GAB2-associated genes across cancer lineages are ACY3, ZEB2, and SLC15A1. Each is linked with GAB2 in more than 2 cancer types. Because this analysis shows association rather than direction, both GAB2-to-partner and partner-to-GAB2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GAB2 versus ACY3 in BRCA, with a Pearson correlation of -0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAB2→partner) and Y-score (partner→GAB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ACY3 →	-1.418	-0.520	.001	<.001	3	3
UCEC	ZEB2 →	+0.509	+0.249	.008	.005	3	3
LSCC	SLC15A1 →	-1.288	-0.549	<.001	.003	3	3
OV	MRPL48 →	+0.559	+0.408	.002	<.001	3	3
GBM	FCHSD2 →	+0.506	+0.279	<.001	<.001	3	3
GBM	OLIG1 →	+1.027	+0.196	.006	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,657 associations by consensus.

GAB2 vs ACY3 — BRCA

Explore this scatter interactively →