GAB2

Across TCGA patient cohorts, GAB2 mutation is significantly associated with the RNA expression of many other genes, with 4,467 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GAB2-associated genes across cancer lineages are RNA5SP331, RNU6ATAC26P, and TRAJ50. Each is linked with GAB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GAB2-to-partner and partner-to-GAB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP331 grouped by GAB2-low versus GAB2-high in OV.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAB2→partner) and Y-score (partner→GAB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RNA5SP331 →	+0.758	+5.137	<.001	.007	3	2
CESC	RNU6ATAC26P →	+0.330	+4.234	.001	.008	3	2
LUSC	TRAJ50 →	+0.403	+4.724	<.001	.005	3	2
LUSC	OR11J5P →	+0.056	+4.993	<.001	.003	3	2
LUAD	RPL12P48 →	+0.276	+4.218	<.001	.009	3	2
UCEC	RNU6-728P →	+0.086	+2.335	.002	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,467 associations by consensus.

RNA5SP331 by GAB2 expression — OV

Explore this box plot interactively →