GAB2

Across TCGA patient cohorts, GAB2 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GAB2-associated genes across cancer lineages are GAPDH, Lck, and RAD51. Each is linked with GAB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GAB2-to-partner and partner-to-GAB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by GAB2-low versus GAB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAB2→partner) and Y-score (partner→GAB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.509	+2.321	.005	.005	3	2
UCEC	Lck →	+0.178	+1.247	.009	.045	3	2
UCEC	RAD51 →	+0.150	+2.807	.001	.003	3	2
UCEC	ASNS →	+0.412	+2.415	<.001	.003	3	2
UCEC	C-Raf →	+0.131	+1.514	.007	.015	3	2
UCEC	eEF2 →	+0.366	+1.807	.002	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

GAPDH by GAB2 expression — UCEC

Explore this box plot interactively →