GAB2

Across TCGA cell cohorts, GAB2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,230 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible GAB2-associated GO terms across cancer lineages are Post-Golgi vesicle-mediated transport, Vesicle localization, and Endosome to lysosome transport. Each is linked with GAB2 in more than 10 cancer types. Because this analysis shows association rather than direction, both GAB2-to-partner and partner-to-GAB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Post-Golgi vesicle-mediated transport grouped by GAB2-low versus GAB2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GAB2→partner) and Y-score (partner→GAB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Post-Golgi vesicle-mediated transport →	+0.064	+0.964	.002	.002	3	11
STOMACH	Vesicle localization →	+0.059	+2.404	<.001	<.001	3	9
LARGE_INTESTINE	Endosome to lysosome transport →	+0.051	+0.988	<.001	.004	2	10
BONE	Cytosolic transport →	+0.067	+1.157	.001	.001	3	8
UPPER_AERODIGESTIVE_TRACT	Golgi vesicle transport →	+0.058	+1.179	<.001	<.001	2	9
BONE	Golgi to plasma membrane transport →	+0.087	+1.516	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,230 associations by consensus.

Post-Golgi vesicle-mediated transport by GAB2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →