GAB2

Across TCGA cell cohorts, GAB2 mutation is significantly associated with the mutation status of many other genes, with 1,283 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GAB2-associated genes across cancer lineages are SSH1, MYBPC3, and MBTD1. Each is linked with GAB2 in more than 3 cancer types. Because this analysis shows association rather than direction, both GAB2-to-partner and partner-to-GAB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SSH1 grouped by GAB2-low versus GAB2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAB2→partner) and Y-score (partner→GAB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SSH1 →	+5.014	+5.584	.003	.003	1	4
BLOOD_Leukemia	MYBPC3 →	+3.285	+3.662	.004	.004	1	4
BLOOD_Leukemia	MBTD1 →	+5.285	+4.321	.005	.005	1	3
BLOOD_Leukemia	CPS1 →	+3.548	+3.845	.003	.003	1	3
BLOOD_Lymphoma	MAST1 →	+4.014	+4.969	.008	.008	1	3
BLOOD_Lymphoma	OGDH →	+4.429	+5.247	.005	.005	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,283 associations by consensus.

SSH1 by GAB2 expression — BLOOD_Lymphoma

Explore this box plot interactively →