GAB1

Across TCGA pan-cancer cohorts, GAB1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated GAB1 data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GAB1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated GAB1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, CCRCC, and PDAC are the cancer types where GAB1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	III,IV	0.834	0.335	<.001	69	view →
CCRCC	DFS	Tertile	III,IV	0.809	0.280	<.001	40	view →
PDAC	DFS	Tertile	All	0.553	0.315	.003	21	view →
LUAD	DFS	Median	All	0.845	0.504	.025	7	view →
LSCC	DFS	Quartile	All	0.480	1.000	.022	3	view →
GBM	DFS	Tertile	All	0.256	0.458	.033	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

GAB1–HNSC (DFS)

Open the HNSC breakdown →