GAB1

Across TCGA cell cohorts, GAB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,256 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GAB1-associated GO terms across cancer lineages are Regulation of macroautophagy, Positive regulation of canonical Wnt signaling pathway, and Protein destabilization. Each is linked with GAB1 in more than 11 cancer types. Because this analysis shows association rather than direction, both GAB1-to-partner and partner-to-GAB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of macroautophagy grouped by GAB1-low versus GAB1-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GAB1→partner) and Y-score (partner→GAB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of macroautophagy →	+0.071	+1.447	.007	.003	3	12
LUNG_NSCLC_LUSC	Positive regulation of canonical Wnt signaling pathway →	+0.080	+1.954	<.001	<.001	3	11
LUNG_NSCLC_LUAD	Protein destabilization →	+0.064	+0.925	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Macroautophagy →	+0.071	+0.923	<.001	<.001	3	10
STOMACH	Negative regulation of chromosome condensation →	+0.160	+1.440	.001	.001	3	10
LUNG_NSCLC_LUAD	Vacuolar transport →	+0.058	+1.136	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,256 associations by consensus.

Regulation of macroautophagy by GAB1 expression — STOMACH

Explore this box plot interactively →