GAB1

Across TCGA cell cohorts, GAB1 mutation is significantly associated with the RNA expression of many other genes, with 35 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible GAB1-associated genes across cancer lineages are OR52L1, OR52E4, and BPIFA2. Each is linked with GAB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GAB1-to-partner and partner-to-GAB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR52L1 grouped by GAB1-low versus GAB1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAB1→partner) and Y-score (partner→GAB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR52L1 →	+0.052	+3.947	.003	.004	3	2
LUNG_NSCLC_LUAD	OR52E4 →	+0.096	+3.947	<.001	.004	3	2
SOFT_TISSUE	BPIFA2 →	+0.029	+3.297	<.001	.008	3	1
SOFT_TISSUE	LGALS9B →	+0.599	+3.597	<.001	.006	3	1
SOFT_TISSUE	DNAAF6 →	+0.023	+4.781	<.001	<.001	3	1
BLOOD_Lymphoma	F9 →	+0.025	+3.523	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

OR52L1 by GAB1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →