GAA

Across TCGA pan-cancer cohorts, GAA mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated GAA data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher GAA mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated GAA expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

COAD, UCEC, and LSCC are the cancer types where GAA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	All	0.878	1.000	.042	12	view →
UCEC	OS	Tertile	III,IV	0.322	1.000	.022	8	view →
LSCC	DFS	Median	All	0.405	0.911	.002	8	view →
GBM	OS	Quartile	All	0.669	0.924	.005	7	view →
HNSC	DFS	Quartile	III,IV	0.579	1.000	.036	3	view →
LUAD	DFS	Quartile	II,III,IV	0.621	0.324	.032	2	view →
CCRCC	DFS	Median	III,IV	0.461	0.660	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

GAA–COAD (DFS)

Open the COAD breakdown →