GAA

Across TCGA patient cohorts, GAA RNA expression is significantly associated with the protein abundance of many other proteins, with 10,674 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GAA-associated proteins across cancer lineages are C1QC, SPP1_S234, and SPP1_S62. Each is linked with GAA in more than 4 cancer types. Because this analysis shows association rather than direction, both GAA-to-partner and partner-to-GAA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GAA versus C1QC in GBM, with a Pearson correlation of 0.27.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GAA→partner) and Y-score (partner→GAA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	C1QC →	+0.620	+0.509	.002	.006	2	5
LSCC	SPP1_S234 →	+1.661	+0.660	<.001	<.001	3	4
LSCC	SPP1_S62 →	+1.546	+0.762	<.001	<.001	3	4
LSCC	TBC1D2 →	+0.430	+0.537	<.001	.005	3	4
CCRCC	TSHZ1_S671 →	-1.135	-0.676	<.001	<.001	3	4
PDAC	VIM_S73 →	+0.595	+0.431	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,674 associations by consensus.

GAA vs C1QC — GBM

Explore this scatter interactively →