GAA

Across TCGA patient cohorts, GAA protein abundance is significantly associated with the RNA expression of many other genes, with 12,486 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GAA-associated genes across cancer lineages are CDC20, CDCA5, and MR1. Each is linked with GAA in more than 4 cancer types. Because this analysis shows association rather than direction, both GAA-to-partner and partner-to-GAA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GAA versus CDC20 in BRCA, with a Pearson correlation of -0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAA→partner) and Y-score (partner→GAA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CDC20 →	-1.359	-0.491	<.001	<.001	3	5
GBM	CDCA5 →	-1.019	-0.487	<.001	<.001	3	5
GBM	MR1 →	+0.632	+0.524	<.001	<.001	3	5
GBM	GPNMB →	+1.216	+0.355	<.001	<.001	3	5
GBM	ESCO2 →	-0.911	-0.445	<.001	<.001	3	5
LUAD	RAD51 →	-0.663	-0.302	.003	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,486 associations by consensus.

GAA vs CDC20 — BRCA

Explore this scatter interactively →