GAA

Across TCGA patient cohorts, GAA protein abundance is significantly associated with the protein abundance of many other proteins, with 18,701 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GAA-associated proteins across cancer lineages are HEXA, NAGA, and NPC2. Each is linked with GAA in more than 8 cancer types. Because this analysis shows association rather than direction, both GAA-to-partner and partner-to-GAA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GAA versus HEXA in GBM, with a Pearson correlation of 0.65.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GAA→partner) and Y-score (partner→GAA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HEXA →	+0.510	+0.431	<.001	<.001	3	9
COAD	NAGA →	+0.552	+0.632	<.001	<.001	3	8
GBM	NPC2 →	+0.813	+0.463	<.001	<.001	3	8
COAD	CTSZ →	+0.805	+0.668	<.001	<.001	3	7
CCRCC	FUCA1 →	+0.659	+0.276	<.001	<.001	3	7
OV	GLB1 →	+0.486	+0.517	.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,701 associations by consensus.

GAA vs HEXA — GBM

Explore this scatter interactively →