GAA

Across TCGA patient cohorts, GAA mutation is significantly associated with the RNA expression of many other genes, with 2,295 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GAA-associated genes across cancer lineages are EMC3-AS1, C4orf46, and LACTB. Each is linked with GAA in more than 3 cancer types. Because this analysis shows association rather than direction, both GAA-to-partner and partner-to-GAA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EMC3-AS1 grouped by GAA-low versus GAA-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAA→partner) and Y-score (partner→GAA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	EMC3-AS1 →	+0.661	+3.826	<.001	<.001	3	3
SKCM	C4orf46 →	+0.630	+3.350	.002	.005	3	3
COAD	LACTB →	+0.468	+3.352	.004	.005	2	4
SKCM	FAM114A2 →	+0.529	+3.272	.004	.008	3	3
UCEC	LARS2 →	+0.443	+1.864	.002	.004	3	3
UCEC	SCO1 →	+0.569	+2.389	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,295 associations by consensus.

EMC3-AS1 by GAA expression — SKCM

Explore this box plot interactively →