GAA

Across TCGA cell cohorts, GAA RNA expression is significantly associated with the go_rna of many other GO terms, with 3,605 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GAA-associated GO terms across cancer lineages are Disaccharide metabolic process, Respiratory system process, and Respiratory gaseous exchange by respiratory system. Each is linked with GAA in more than 19 cancer types. Because this analysis shows association rather than direction, both GAA-to-partner and partner-to-GAA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Disaccharide metabolic process grouped by GAA-low versus GAA-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GAA→partner) and Y-score (partner→GAA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Disaccharide metabolic process →	+0.312	+0.871	.005	.002	3	20
LUNG_SCLC	Respiratory system process →	+0.277	+1.533	<.001	<.001	3	19
LUNG_NSCLC_LUSC	Respiratory gaseous exchange by respiratory system →	+0.205	+1.796	<.001	<.001	3	15
OESOPHAGUS	Negative regulation of myoblast fusion →	+0.117	+1.333	.006	.003	2	15
KIDNEY	Monosaccharide metabolic process →	+0.106	+1.687	<.001	<.001	3	13
OESOPHAGUS	Regulation of myoblast fusion →	+0.111	+1.160	.003	.009	2	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,605 associations by consensus.

Disaccharide metabolic process by GAA expression — LUNG_SCLC

Explore this box plot interactively →