GAA

Across TCGA cell cohorts, GAA mutation is significantly associated with the RNA expression of many other genes, with 395 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GAA-associated genes across cancer lineages are SLC22A9, C6orf118, and IFNA1. Each is linked with GAA in more than 1 cancer types. Because this analysis shows association rather than direction, both GAA-to-partner and partner-to-GAA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC22A9 grouped by GAA-low versus GAA-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAA→partner) and Y-score (partner→GAA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SLC22A9 →	+0.029	+5.169	<.001	<.001	3	2
BLOOD_Myeloma	C6orf118 →	+0.113	+4.807	<.001	.006	3	1
BLOOD_Myeloma	IFNA1 →	+0.030	+4.807	<.001	.006	3	1
SOFT_TISSUE	TSPY2 →	+0.029	+4.369	<.001	.008	3	1
SOFT_TISSUE	OR4C6 →	+0.039	+4.369	<.001	.008	3	1
SOFT_TISSUE	OR52J3 →	+0.016	+4.369	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 395 associations by consensus.

SLC22A9 by GAA expression — SOFT_TISSUE

Explore this box plot interactively →