G6PD

Across TCGA patient cohorts, G6PD RNA expression is significantly associated with the protein abundance of many other proteins, with 12,146 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible G6PD-associated proteins across cancer lineages are GCLM, G6PD_Y401, and TKT. Each is linked with G6PD in more than 5 cancer types. Because this analysis shows association rather than direction, both G6PD-to-partner and partner-to-G6PD results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, G6PD versus GCLM in LSCC, with a Pearson correlation of 0.77.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (G6PD→partner) and Y-score (partner→G6PD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GCLM →	+1.055	+1.448	<.001	<.001	3	6
BRCA	G6PD_Y401 →	+0.836	+1.261	<.001	<.001	3	5
HNSC	TKT →	+0.473	+1.360	<.001	<.001	3	5
LUAD	TSFM →	+0.447	+0.911	<.001	<.001	3	5
LSCC	TXNRD1 →	+0.953	+1.566	<.001	<.001	3	5
LSCC	MAP1B_T1788 →	+1.063	+0.917	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,146 associations by consensus.

G6PD vs GCLM — LSCC

Explore this scatter interactively →