G6PD

Across TCGA patient cohorts, G6PD protein abundance is significantly associated with the RNA expression of many other genes, with 17,424 significant associations in total. GBM shows the largest number of these associations.

The most reproducible G6PD-associated genes across cancer lineages are NMRAL2P, ME1, and LUCAT1. Each is linked with G6PD in more than 6 cancer types. Because this analysis shows association rather than direction, both G6PD-to-partner and partner-to-G6PD results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, G6PD versus NMRAL2P in LSCC, with a Pearson correlation of 0.65.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (G6PD→partner) and Y-score (partner→G6PD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NMRAL2P →	+4.024	+0.919	<.001	<.001	3	7
LSCC	ME1 →	+1.649	+0.921	<.001	<.001	3	7
GBM	LUCAT1 →	+1.219	+0.481	<.001	<.001	3	6
GBM	LYN →	+0.809	+0.408	<.001	<.001	3	6
LSCC	LINC02561 →	+2.347	+0.851	<.001	<.001	3	6
LSCC	GCLM →	+1.949	+0.895	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,424 associations by consensus.

G6PD vs NMRAL2P — LSCC

Explore this scatter interactively →