G6PD

Across TCGA cell cohorts, G6PD RNA expression is significantly associated with the go_rna of many other GO terms, with 4,326 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible G6PD-associated GO terms across cancer lineages are Response to iron(III) ion, Response to L-phenylalanine derivative, and Pentose-phosphate shunt, oxidative branch. Each is linked with G6PD in more than 19 cancer types. Because this analysis shows association rather than direction, both G6PD-to-partner and partner-to-G6PD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to iron(III) ion grouped by G6PD-low versus G6PD-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (G6PD→partner) and Y-score (partner→G6PD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Response to iron(III) ion →	+0.259	+3.316	<.001	<.001	3	20
LIVER	Response to L-phenylalanine derivative →	+0.165	+2.458	.004	<.001	3	12
BLOOD_Lymphoma	Pentose-phosphate shunt, oxidative branch →	+0.137	+0.908	<.001	<.001	3	12
SOFT_TISSUE	Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway →	+0.171	+1.344	<.001	<.001	3	11
BONE	Protein targeting to vacuole involved in autophagy →	+0.249	+1.482	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Tertiary alcohol metabolic process →	+0.445	+3.050	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,326 associations by consensus.

Response to iron(III) ion by G6PD expression — LIVER

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