G6PC3

Across TCGA patient cohorts, G6PC3 mutation is significantly associated with the RNA expression of many other genes, with 317 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible G6PC3-associated genes across cancer lineages are MIR615, OR2L3, and RNU6-497P. Each is linked with G6PC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both G6PC3-to-partner and partner-to-G6PC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR615 grouped by G6PC3-low versus G6PC3-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (G6PC3→partner) and Y-score (partner→G6PC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MIR615 →	+0.528	+5.411	<.001	.005	3	2
BLCA	OR2L3 →	+0.108	+5.411	<.001	.005	3	1
CESC	RNU6-497P →	+0.511	+5.201	<.001	.007	3	1
CESC	ARPP19P1 →	+0.161	+5.010	<.001	.009	3	1
UCEC	H2BC14 →	+0.595	+3.202	.002	.009	3	1
UCEC	MIR6793 →	+0.676	+2.969	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 317 associations by consensus.

MIR615 by G6PC3 expression — BLCA

Explore this box plot interactively →