G6PC3

Across TCGA cell cohorts, G6PC3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,260 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible G6PC3-associated GO terms across cancer lineages are Vesicle uncoating, Multi-pass transmembrane protein insertion into ER membrane, and Cellular response to morphine. Each is linked with G6PC3 in more than 10 cancer types. Because this analysis shows association rather than direction, both G6PC3-to-partner and partner-to-G6PC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Vesicle uncoating grouped by G6PC3-low versus G6PC3-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (G6PC3→partner) and Y-score (partner→G6PC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Vesicle uncoating →	+0.091	+0.629	.007	.002	3	11
CNS	Multi-pass transmembrane protein insertion into ER membrane →	+0.118	+0.770	<.001	<.001	3	10
LUNG_NSCLC_LUAD	Cellular response to morphine →	+0.151	+0.504	<.001	.002	3	9
LUNG_NSCLC_LUAD	Cellular response to isoquinoline alkaloid →	+0.151	+0.504	<.001	.002	3	9
LUNG_SCLC	Cellular detoxification of aldehyde →	+0.135	+0.703	.001	.002	3	8
BONE	Intracellular sphingolipid homeostasis →	+0.093	+0.502	.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,260 associations by consensus.

Vesicle uncoating by G6PC3 expression — BLOOD_Lymphoma

Explore this box plot interactively →