G6PC3

Across TCGA cell cohorts, G6PC3 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible G6PC3-associated genes across cancer lineages are ITGAD and PRAMEF20. Each is linked with G6PC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both G6PC3-to-partner and partner-to-G6PC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ITGAD grouped by G6PC3-low versus G6PC3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (G6PC3→partner) and Y-score (partner→G6PC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ITGAD →	+0.015	+4.095	<.001	.009	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.015	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

ITGAD by G6PC3 expression — LARGE_INTESTINE

Explore this box plot interactively →