G6PC2

Across TCGA patient cohorts, G6PC2 mutation is significantly associated with the RNA expression of many other genes, with 3,633 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible G6PC2-associated genes across cancer lineages are CCT5, PRSS53, and SKA1. Each is linked with G6PC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both G6PC2-to-partner and partner-to-G6PC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCT5 grouped by G6PC2-low versus G6PC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (G6PC2→partner) and Y-score (partner→G6PC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCT5 →	+0.529	+4.054	<.001	<.001	3	2
UCEC	PRSS53 →	+0.231	+2.991	<.001	<.001	3	2
UCEC	SKA1 →	+0.691	+2.180	<.001	<.001	3	2
UCEC	NDUFAF6 →	+0.281	+2.496	.009	<.001	3	2
UCEC	SEC13 →	+0.354	+2.939	<.001	<.001	3	2
UCEC	PAXIP1 →	+0.419	+2.169	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,633 associations by consensus.

CCT5 by G6PC2 expression — UCEC

Explore this box plot interactively →