G3BP2

Across TCGA patient cohorts, G3BP2 mutation is significantly associated with the RNA expression of many other genes, with 2,112 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible G3BP2-associated genes across cancer lineages are RBMY1F, EIF3JP1, and TUBB8P3. Each is linked with G3BP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both G3BP2-to-partner and partner-to-G3BP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBMY1F grouped by G3BP2-low versus G3BP2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (G3BP2→partner) and Y-score (partner→G3BP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RBMY1F →	+0.012	+7.473	<.001	.007	3	2
BRCA	EIF3JP1 →	+0.174	+4.875	.001	.002	3	2
SKCM	TUBB8P3 →	+0.064	+5.097	<.001	.008	3	2
UCEC	RNU6-5P →	+0.398	+1.630	<.001	.001	3	2
UCEC	RNU6-1213P →	+0.134	+3.019	<.001	.001	3	2
BRCA	PPIAL4F →	+0.076	+4.448	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,112 associations by consensus.

RBMY1F by G3BP2 expression — BRCA

Explore this box plot interactively →