G3BP2

Across TCGA patient cohorts, G3BP2 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible G3BP2-associated genes across cancer lineages are JNK2, EGFR_pY1068, and A-Raf_pS299. Each is linked with G3BP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both G3BP2-to-partner and partner-to-G3BP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by G3BP2-low versus G3BP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (G3BP2→partner) and Y-score (partner→G3BP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.176	+1.584	.008	.009	3	2
UCEC	EGFR_pY1068 →	-0.263	-2.415	.001	.003	3	1
UCEC	A-Raf_pS299 →	-0.123	-1.700	.002	.042	3	1
UCEC	ERK2 →	+0.179	+1.584	.005	.009	3	1
UCEC	JNK_pT183_Y185 →	-0.179	-1.906	.001	.014	3	1
UCEC	Ku80 →	+0.182	+1.335	.021	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

JNK2 by G3BP2 expression — UCEC

Explore this box plot interactively →