G3BP2

Across TCGA cell cohorts, G3BP2 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible G3BP2-associated genes across cancer lineages are TBC1D21, MMP26, and OR6Q1. Each is linked with G3BP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both G3BP2-to-partner and partner-to-G3BP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBC1D21 grouped by G3BP2-low versus G3BP2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (G3BP2→partner) and Y-score (partner→G3BP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TBC1D21 →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	MMP26 →	+0.033	+3.217	<.001	.006	3	1
LARGE_INTESTINE	OR6Q1 →	+0.012	+3.700	<.001	.009	3	1
BREAST	OOSP4B →	+0.040	+5.781	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

TBC1D21 by G3BP2 expression — LARGE_INTESTINE

Explore this box plot interactively →