G3BP1P1

Across TCGA pan-cancer cohorts, G3BP1P1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of G3BP1P1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where G3BP1P1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types G3BP1P1 is over-expressed in tumor.

HNSC, LUAD, and COAD are the cancer types where G3BP1P1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in G3BP1P1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.159	<.001	11	view →
LUAD	Male	II,III,IV	+0.314	<.001	8	view →
COAD	All	II,III,IV	+0.260	<.001	8	view →
KIRC	All	All	+0.065	<.001	8	view →
LUSC	Male	II,III,IV	+0.371	<.001	7	view →
KIRP	All	III,IV	+0.191	.002	7	view →
UCEC	All	All	+0.248	.004	6	view →
BRCA	All	All	+0.239	<.001	6	view →
STAD	All	II,III,IV	+0.216	<.001	6	view →
BLCA	All	All	+0.264	.005	5	view →
CHOL	All	All	+0.343	.004	2	view →
PRAD	All	All	+0.055	.036	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

G3BP1P1–HNSC

Open the HNSC breakdown →