Across TCGA patient cohorts, FZD9 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FZD9-associated genes across cancer lineages are Akt, eEF2, and EGFR_pY1068. Each is linked with FZD9 in more than 1 cancer types. Because this analysis shows association rather than direction, both FZD9-to-partner and partner-to-FZD9 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FZD9→partner) and Y-score (partner→FZD9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt →	-0.195	-2.105	.033	.017	3	2
UCEC	eEF2 →	+0.363	+2.415	.011	.003	3	1
UCEC	EGFR_pY1068 →	-0.253	-1.906	.012	.016	3	1
UCEC	FOXO3a_pS318_S321 →	-0.116	-1.797	.020	.025	3	1
UCEC	MEK1 →	+0.390	+2.321	.008	.033	3	1
UCEC	MSH2 →	-0.355	-3.295	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Exploration

FZD9 survival (RNA) · tumor vs normal (RNA) · all FZD9 data types