FZD8

Across TCGA patient cohorts, FZD8 protein abundance is significantly associated with the RNA expression of many other genes, with 884 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible FZD8-associated genes across cancer lineages are SEH1L, ALKBH1, and MYBL2. Each is linked with FZD8 in more than 1 cancer types. Because this analysis shows association rather than direction, both FZD8-to-partner and partner-to-FZD8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FZD8 versus SEH1L in LSCC, with a Pearson correlation of -0.27.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FZD8→partner) and Y-score (partner→FZD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SEH1L →	-0.458	-0.637	.005	.007	3	2
UCEC	ALKBH1 →	-0.192	-0.509	.001	<.001	3	1
UCEC	MYBL2 →	-1.100	-0.584	<.001	.001	3	1
UCEC	E2F1 →	-0.823	-0.632	.001	<.001	3	1
UCEC	KNOP1 →	-0.464	-0.842	.001	<.001	3	1
UCEC	GOLGA8UP →	-0.449	-0.541	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 884 associations by consensus.

FZD8 vs SEH1L — LSCC

Explore this scatter interactively →