FZD8

Across TCGA patient cohorts, FZD8 mutation is significantly associated with the RNA expression of many other genes, with 2,153 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FZD8-associated genes across cancer lineages are COX15, CENPN, and LEO1. Each is linked with FZD8 in more than 2 cancer types. Because this analysis shows association rather than direction, both FZD8-to-partner and partner-to-FZD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COX15 grouped by FZD8-low versus FZD8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FZD8→partner) and Y-score (partner→FZD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	COX15 →	+0.396	+3.375	.002	.004	3	3
UCEC	CENPN →	+0.540	+3.721	.002	<.001	3	3
UCEC	LEO1 →	+0.435	+3.732	.002	<.001	3	3
UCEC	RRM1 →	+0.649	+2.606	.002	.005	3	3
UCEC	FEN1 →	+0.623	+3.000	.001	.001	3	3
COAD	TIMM22 →	+0.425	+3.199	.006	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,153 associations by consensus.

COX15 by FZD8 expression — UCEC

Explore this box plot interactively →